The safety and efficacy of an oral penicillin challenge program in cancer patients: A multicenter pilot study

JA Trubiano; O Smibert; A Douglas; M Devchand; B Lambros; NE Holmes; KY Chua; EJ Phillips; MA Slavin

Journal article

The safety and efficacy of an oral penicillin challenge program in cancer patients: A multicenter pilot study

JA Trubiano, O Smibert, A Douglas, M Devchand, B Lambros, NE Holmes, KY Chua, EJ Phillips, MA Slavin

Open Forum Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018

DOI: 10.1093/ofid/ofy306

Download PDF

Abstract

Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the cancer diagnosis. We demonstrate the successful and safe implementation of a pilot oral penicillin challenge program for cancer patients with low-risk penicillin allergies, increasing the use of penicillin and narrow-spectrum beta-lactams post-testing.

University of Melbourne Researchers

Jason Trubiano Author

Natasha Holmes Author

Kyra Chua Author

Monica Slavin Author

Related Projects (2)

NATIONAL CENTRE FOR INFECTIONS IN CANCER (NCIC)

This Centre of Research Excellence will translate the best available evidence to improve cancer outcomes through better management of infect..

DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS

Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of ..

Grants

Awarded by Peter MacCallum Cancer Centre

Funding Acknowledgements

J.A.T. is supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (GNT 1139902) and a postgraduate scholarship from the National Centre for Infections in Cancer (NCIC), Peter MacCallum Cancer Centre (Melbourne, Australia). B.L. and M.A.S. are supported by an NHMRC Centres of Research Excellence grant (GNT 1116876). N.E.H. is supported by an NHMRC Early Careers Fellowship (GNT 1073378).